Kilobaser - The "DNA Nespresso Machine"
- Kilobaser allows scientists to custom-make specific molecules for studying diseases, developing new medicines, and creating genetically modified organisms.
- Briefcase Biotec planned to sell 1,000 kilobases per year worldwide from 2019.
- Kilobaser was mentioned among the top 90 biotechnology startups in Austria in 2021.
DNA is the blueprint of all lifeforms, and deciphering its code is critical. Being able to create DNA molecules supports research and advancement in the medical industry.
A DNA synthesizer takes a code and builds a DNA molecule one piece at a time. It can be compared to a 3D printer for molecules.
Kilobaser - The DNA Nespresso Machine
“DNA is the foundation of life science – why can’t we synthesize DNA ourselves?” was the question that circled around CEO and founder Alexander Murer’s head.
Before Kilobaser, scientists often depended on large companies to obtain DNA molecules and then waited days or weeks for delivery. This slowed the research process.
Taking inspiration from a Nespresso machine, founders Alexander Murer, Martin Jost, and Bernhard Tittlebach developed a user-friendly and affordable printer that could synthesize DNA directly in the lab.
Founded in 2014 in Graz, Austria, Briefcase Biotec had one vision for Kilobaser: give researchers the ability to create custom DNA molecules faster, easier, and on demand.
Kilobaser’s DNA synthesis system
Kilobaser’s design uses disposable cartridges and microfluidic technology. Microfluidics is a miniaturized system that controls fluids on a microchip.
The technology allows researchers to synthesize DNA primers directly in their labs within an hour. DNA primers are short strands of DNA that serve as starting points for research with DNA.
The system’s affordability and user-friendly interface also allow use in smaller labs and academic institutions that may not have access to traditional methods.
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In 2018, four years after its creation, Kilobaser launched its first Kilobaser Series 0 machines.
Its microfluidic LOC, or lab-on-a-chip, technology offers advantages over traditional organic chemistry-based synthesizers.
The cartridge system provides a 100-fold reduction in reagent consumption. It enables the synthesis of DNA, RNA, probes, and modified oligos directly at the researcher’s fingertips.
Kilobaser’s expansion
Kilobaser partnered with Focus Academy by opening a U.S. office to support distribution with American researchers.
Kilobaser also appointed Meiwafosis as its exclusive distributor in Japan.
The global DNA synthesizer market is expected to reach over $754 million by 2031.
Kilobaser continues to operate and offer DNA synthesis systems in 2026.
With its Kilobaser system, Briefcase Biotec is well-positioned to be a key player in this field.
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